Genetics and Addiction

Family generation green eyes genetics concept

I’ve read a lot recently about the link between genetics and addiction. I thought it was worth doing a post clarifying the position.

The starting point, I think, is that genetics cannot dictate behaviour. Behaviour is learned, not inherited. There is no gene that can make you compulsively keep picking up a drink and drinking it.

Some people will say that certain mental health issues are inheritable (ie they are passed to us via our genes) and people with those mental health issues are more prone to problem drinking. This is not evidence that the propensity to addiction is inheritable. It just highlights a point that I have made many times before; if something is not right with us, for example, if we have a genuine mental health issue, then we will want to negate or sedate it. What is the most readily available sedative out there? What sedative can we get prescription free, in quantities only limited by how much we can afford and carry? In fact, there is only one; alcohol. So people with mental health issues may very well be more prone to drink, and drink more, and therefore develop a dependency on alcohol. But this is not evidence that they have a genetic disposition to addiction. They may have a genetic predisposition to their mental health problem, but they do not have a genetic predisposition to seek to anesthetise that problem with alcohol. The mental health issue may be genetic (or partly genetic), but the use of alcohol to mask the issue is behavioural.

Some people will say that they had an ability to drink more from early on, and this is proof that they are genetically different where alcohol is concerned. Gender, body weight, and muscle mass can all dictate how much alcohol we can cope with. There are other things as well. Alcohol is processed in the body by it first being metabolized by an enzyme called ‘alcohol dehydrogenase’ which changes the alcohol into a compound called acetaldehyde. Acetaldehyde is poisonous to humans and is further metabolised in the body by an enzyme called ‘aldehyde dehydrogenase.’

Some people are deficient in aldehyde dehydrogenase, which can lead to a build-up of acetaldehyde in the blood. What this means in practice is that they suffer more from the ill effects of drinking and can therefore drink less. Certain ethnic groups are more likely to have this enzyme deficiency. So some people are, for genetic reasons, able to drink more than others, and of course, the more you drink the quicker you will develop dependency. But does this mean you have inherited a genetic predisposition to addiction? I would say absolutely not.

people making choices

Some of us are born with stronger bodies than others, this may be due to our genetics, but what we do with those bodies, specifically whether we chose to use them to regularly consume drugs is nothing to do with genetics, that is purely behavioural. 

It is also worth coming at it from the other side. If there was someone with absolutely no mental health issues, and a deficiency in aldehyde dehydrogenase, they could still become alcohol dependent simply because the human brain and body are incredibly adaptive. Alcohol is a sedative, and the brain reacts to it by becoming hypersensitive so that it can still work while under the sedating effects of the alcohol. When the alcohol wears off the oversensitivity remains, leaving us feeling out of sorts, anxious, and more easily derailed by life’s ups and downs. The quickest way to rectify this chemical imbalance is to take another drink which leaves us feeling calm, confident, resilient, and able to properly marshal our thoughts (in other words it leaves us feeling exactly how we were before we started drinking). This is the basic chemical process in alcohol addiction. This process is the same for every human being on the planet.

What I think is perhaps more interesting when talking about this topic is why so many people believe that they have this genetic propensity for addiction because it’s a similar reason why people are so quick to believe in the fabled health benefits of drinking.

As I’ve covered, when the alcohol wears off we’re left feeling anxious, out of sorts, unable to get things into perspective, easily overwhelmed, unable to relax, and uptight. This is all caused by the chemical imbalance caused by our previous intake. If we then have a drink we immediately correct that chemical imbalance, after all the imbalance is there because our brain is on hyper drive so it can work under the sedating effects of the alcohol but there isn’t any alcohol there. So a drink will immediately correct that chemical imbalance and get us back to feeling calm and confident.

So our personal experience of drinking is that we feel unpleasant and out of sorts and just plain wrong, and a drink makes us feel confident and capable and above all, much much happier.

We, humans, like to think we are rational, pragmatic creatures, but we aren’t. Our reality is made up primarily of our own experiences and we have a great tendency to look for any theory that fits in with our experiences. As Annie Grace says in This Naked Mind:

people looking through glasses

“One reason is that we unconsciously self-seal them [our beliefs] by seeking out things that are congruent with them. This is called confirmation bias, the tendency to search for or interpret information in a way that confirms one’s pre- conceptions.”

Because our experience is that we feel ‘wrong’ without alcohol, and ‘right’ with it, we very easily believe two myths.

The first of these myths is that alcohol is good for us. Despite all the evidence to the contrary, all the simple common-sense science that says that there are no health benefits to alcohol whatsoever, it remains a pervading belief that alcohol is good for us. If we are tired, hungry, drained and washed out, a healthy meal will make us feel a whole world better. This is one of the ways that animals learn to consume foods that are good for them; foods that suit them will make them feel good. So a claim that alcohol has health benefits is just too difficult for most people to resist because it fits too perfectly with their personal beliefs. It makes me feel good, how can it possibly be bad for me?

The second of these myths is that we have a genetic requirement for alcohol. After all, we don’t feel right when we aren’t drinking, in fact, we feel quite wrong. And a drink makes us feel right. So a theory that states that we have some kind of physical / genetic deficiency that means we have to drink alcohol to feel at our best fits perfectly with our experiences of our own drinking, so it becomes a very easy myth to believe. This is exacerbated because when we learn on a subconscious level that the unpleasant feeling that is left behind when a drink wears off can be alleviated by another drink, moderating or controlling our intake becomes increasingly difficult because each drink creates the need for the next. At this point, we are no longer like ‘normal’ drinkers, because they can take it or leave it (or so they would have us believe) whereas we can’t. This feeds into the belief that we are different from them. In fact, we are, but that difference isn’t genetic, it’s simply that our subconscious has learned something that theirs has yet to learn; that when a drink wears off you need another one to chase that feeling of confidence and relaxation that we who have seen the truth and finally quit drinking for a good experience all the time.

Again this isn’t genetic. It is learned behaviour.

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12 Responses

    1. Thank you I will take a look, but I think passing a memory on and passing on a flawed coping mechanism might be very different.

  1. Well said and thank you! I’ve learned a lot from both your books and Annie Grace’s This Naked Mind. I’m a little over a year without a drink and zero desire for alcohol today. Thanks for helping to re-train my sub-conscious mind!

    1. All this shows is that there are certain genetic strain common among people with AUD. As I say in the post I am not arguing that, there will be differences that mean people may be stronger and better able to metabolise alcohol, which makes them more likely to drink more a develop dependency. But that isn’t a gene making you more prone to addiction. That’s just giving you a stronger body. It is behaviour, not genetics, that dictates whether a person then uses that body to consume regular quantities of an addictive drug.

  2. I read your article with great interest and summarizes your point quit accurately. However the reason I made the initial comments prior to this message was that your initial comment seemed to suggest that AUD was a learned behavior that some would define as a habit and nothing to do with genetics?? To try and break this habit as virtually every habit is rooted in an attempt to feel better they can start in a way to leave the present moment by numbing out the emotions temporarily and if alcohol is the habit the disrupted dopamine neurotransmitters will give some semblance of calmness and return to normalcy. “Instead, ending your habit is about deeply connecting with the truth of who you are and attempting to seeing the true nature of your habit and yourself” I never put in my high school year book that when I grow up, I want to be like my father. I love your insight! 9 months and 16 day AF.

  3. I appreciate all the work you have been doing, and I have been reading parts of Alcohol Explained. I agree that alcohol consumption is a learned behaviour. Would you agree that many people have a genetic predisposition to depression, and that people from rich nations who suffer depression have a greater predisposition for substance abuse? This appears to be true, and does not indicate a direct link, but does describe an indirect genetic predisposition.

    1. That could well be true, but the I think the key is that let’s assume someone has depression and this is genetic. There may be lots of ways you can deal with or improve this. Alcohol is way down on that list, as it increases depression nod anxiety dramatically. So say there’s 20 to deal with it, one of which is drinking. What makes them chose drinking as a coping mechanism? I would say misinformation, not genetics.

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William Porter

William wrote Alcohol Explained to share his approach on recovering from alcohol dependency.

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